Non sedating antihistamines in children
The prevalence of CU in children is reported to vary between 0.1 and 0.3 %.
The natural history of CU in children tends toward spontaneous resolution: approximately 25 % of patients go into remission within 3 years.
It is recommended that bilastine be administered at least 1 hour before or 2 hours after a meal.Bilastine does not undergo any significant metabolism, and approximately 95 % is excreted in the feces or urine.There is no interaction with cytochrome P450 (CYP) in the liver, and bilastine also does not interact with any other drug, except for ketoconazole, erythromycin, and diltiazem.Clinical studies of bilastine have shown good tolerability of this drug and have not reported severe adverse effects.The most common adverse effects were headache, somnolence, dizziness, and fatigue.
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The absorption of cetirizine is not reduced by food intake; there is no evidence of interaction with alcohol intake.